Overview on Pediatric Myelodysplastic Syndrome: A Review

Alzamami, Jana Fahad and Bamousa, Reema Mohammed and Alotaibi, Rawan Obaid and Alotaibi, Ghadeer Abdullah and Albeladi, Quds Hussain and Almutairi, Sultan Meshal and Alkhamis, Bayan Anwar and Alwahbi, Sultan Salman and Alasmari, Nuha Saad H. and Ashgan, Baraah Atef Madani and Alghamdi, Hussam Yahya Abdullah and Fadl, Ahmed AbdelSamie (2021) Overview on Pediatric Myelodysplastic Syndrome: A Review. Journal of Pharmaceutical Research International. pp. 1-7. ISSN 2456-9119

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Myelodysplastic syndrome (MDS) is a set of clonal bone marrow diseases in children that are characterised by peripheral cytopenia, dysplastic alterations in the bone marrow, and inefficient hematopoiesis. MDS is uncommon in children, with just 1-4 occurrences per million children afflicted. Adults, particularly the elderly, are more susceptible to the disease. Some hereditary disorders, such as Fanconi's anaemia, Shwachman's, and Down's syndromes, are known to predispose children to developing MDS. JCML and monosomy 7 syndrome are the two most frequent paediatric MDS types, both of which affect children in their early years. Approximately 20% of juvenile myelodysplastic syndrome (MDS) cases are discovered by chance during normal laboratory testing or during the course of a suspected hereditary bone marrow failure (IBMF). Differentiating MDS with low blast numbers from aplastic anaemia (AA) and MDS with excess blasts from AML are the two key diagnostic issues in this condition. Bone marrow transplantation and stem cell transplantation is the treatment of choice in most cases. In this article we discuss the disease epidemiology, diagnosis, and treatment.

Item Type: Article
Subjects: Asian Repository > General Subject > Medical Science
0 Subject > Medical Science
Depositing User: Managing Editor
Date Deposited: 29 Jun 2022 03:47
Last Modified: 29 Jun 2022 03:47
URI: http://eprints.asianrepository.com/id/eprint/929

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