Hyseni, Mentor and Zumbrägel, Nadine and Offermanns, Heribert and Gröger, Harald (2019) Expanding the Scope of Asinger Chemistry towards Enantiomerically Pure Secondary Amines and β-Aminothiols through Chemoenzymatic Derivatization of 3-Thiazolines. Chemistry, 1 (1). pp. 180-191. ISSN 2624-8549
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Abstract
A proof of concept for a novel approach towards enantiomerically highly enriched acyclic secondary amines and β-aminothiols as non-cyclic target molecules when starting from 3-thiazolines as heterocycles is presented. Starting from 2,2,4,5,5-pentamethyl-3-thiazoline, we demonstrated this chemoenzymatic pathway to both of these types of amine molecules, which were isolated as urea derivatives with a non-optimized yield of up to 20%. As a substrate, 2,2,4,5,5-pentamethyl-3-thiazolidine, which was obtained with an enantiomeric excess (ee) of 99% in a biotransformation from the corresponding 3-thiazoline according to a recently developed protocol, was used. For the reductive desulfurization of this substrate leading to a sulfur-free secondary amine, in situ formed Ni2B turned out to be a suitable reducing reagent. However, when using lithium aluminum hydride as a reducing agent, β-aminothiol was obtained.
Item Type: | Article |
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Subjects: | Q Science > QD Chemistry |
Depositing User: | APLOS Library |
Date Deposited: | 09 Jul 2022 09:47 |
Last Modified: | 09 Jul 2022 09:47 |
URI: | http://eprints.asianrepository.com/id/eprint/718 |