Shabunin, Anton and Yudin, Vladimir and Dobrovolskaya, Irina and Zinovyev, Evgeny and Zubov, Viktor and Ivan’kova, Elena and Morganti, Pierfrancesco (2019) Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications. Cosmetics, 6 (1). p. 16. ISSN 2079-9284
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Abstract
An electrospinning technique was used for the preparation of a bilayered wound dressing consisting of a layer of aliphatic copolyamide nanofibers and a layer of composite nanofibers from chitosan and chitin nanofibrils filler. Processed dressings were compared with aliphatic copolyamide nanofiber-based wound dressings and control groups. Experimental studies (in vivo treatment of third-degree burns with this dressing) demonstrated that almost complete (up to 97.8%) epithelialization of the wound surface had been achieved within 28 days. Planimetric assessment demonstrated a significant acceleration of the wound healing process. Histological analysis of scar tissue indicated the presence of a significant number of microvessels and a low number of infiltrate cells. In the target group, there were no deaths or purulent complications, whereas in the control group these occurred in 25% and 59.7% of cases, respectively—and, in the copolyamide group, 0% and 11%, respectively. The obtained data show the high efficiency of application of the developed composite chitosan‒copolyamide wound dressings for the treatment of burn wounds.
Item Type: | Article |
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Subjects: | Asian Repository > General Subject > Medical Science 0 Subject > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 28 Jan 2023 07:11 |
Last Modified: | 28 Jan 2023 07:11 |
URI: | http://eprints.asianrepository.com/id/eprint/4935 |