Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications

Shabunin, Anton and Yudin, Vladimir and Dobrovolskaya, Irina and Zinovyev, Evgeny and Zubov, Viktor and Ivan’kova, Elena and Morganti, Pierfrancesco (2019) Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications. Cosmetics, 6 (1). p. 16. ISSN 2079-9284

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An electrospinning technique was used for the preparation of a bilayered wound dressing consisting of a layer of aliphatic copolyamide nanofibers and a layer of composite nanofibers from chitosan and chitin nanofibrils filler. Processed dressings were compared with aliphatic copolyamide nanofiber-based wound dressings and control groups. Experimental studies (in vivo treatment of third-degree burns with this dressing) demonstrated that almost complete (up to 97.8%) epithelialization of the wound surface had been achieved within 28 days. Planimetric assessment demonstrated a significant acceleration of the wound healing process. Histological analysis of scar tissue indicated the presence of a significant number of microvessels and a low number of infiltrate cells. In the target group, there were no deaths or purulent complications, whereas in the control group these occurred in 25% and 59.7% of cases, respectively—and, in the copolyamide group, 0% and 11%, respectively. The obtained data show the high efficiency of application of the developed composite chitosan‒copolyamide wound dressings for the treatment of burn wounds.

Item Type: Article
Subjects: Asian Repository > General Subject > Medical Science
0 Subject > Medical Science
Depositing User: Managing Editor
Date Deposited: 28 Jan 2023 07:11
Last Modified: 28 Jan 2023 07:11

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