Overview of Congenital Hepatic Fibrosis in Pediatrics: A Review

AlAjmi, Fahad Amrh and Aladhadh, Khalid Mohammed A. and Almadi, Ebtesam Ali S. and Al-Wagdani, Naif Mohammed and Alhelali, Mansour Hemaid and Alsuhaymi, Nasser Naif and Banheem, Ahmed Saeed S. and Almujil, Sarah jamal and Fadl, Ahmed Abdelsamie (2021) Overview of Congenital Hepatic Fibrosis in Pediatrics: A Review. Journal of Pharmaceutical Research International. pp. 470-477. ISSN 2456-9119

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Congenital hepatic fibrosis is a rare developmental illness caused by a ductal plate malformation, often known as ciliopathy or fibrocystic liver disease. Hepatosplenomegaly and portal hypertension are two symptoms. The disease affects 1/10000–20000 people. frequently associated with a variety of illnesses caused by genetic abnormalities, such as autosomal recessive polycystic kidney disease (ARPKD) and Caroli syndrome. There hasn't been a way to stop or reverse the progression of congenital hepatic fibrosis until now. Clinical trials of anti-fibrotic medicines such as colchicine, interferon gamma, angiotensin II receptor blockers, pirfenidone, and ursodeoxycholic acid found no significant benefit. The only known cure for CHF is liver transplantation, which is recommended when the condition has progressed to the point when symptoms of liver failure have appeared. In this article we will be making overview of the disease. It’s symptoms and diagnosis, different treatment method, and we will compare some of the articles published about the disease.

Item Type: Article
Subjects: Asian Repository > General Subject > Medical Science
0 Subject > Medical Science
Depositing User: Managing Editor
Date Deposited: 20 Jul 2022 08:08
Last Modified: 20 Jul 2022 08:08
URI: http://eprints.asianrepository.com/id/eprint/1589

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