The FAR protein family of parasitic nematodes

Lok, James B. and Parks, Sophia C. and Nguyen, Susan and Boulanger, Martin J. and Dillman, Adler R. (2022) The FAR protein family of parasitic nematodes. PLOS Pathogens, 18 (4). e1010424. ISSN 1553-7374

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Fatty acid–and retinol-binding proteins (FARs) belong to a unique family of excreted/secreted proteins (ESPs) found exclusively in nematodes. Much of our understanding of these proteins, however, is limited to their in vitro binding characteristics toward various fatty acids and retinol and has provided little insight into their in vivo functions or mechanisms. Recent research, however, has shown that FARs elicit an immunomodulatory role in plant and animal model systems, likely by sequestering lipids involved in immune signaling. This alludes to the intricate relationship between parasitic nematode effectors and their hosts.

Item Type: Article
Subjects: G Geography. Anthropology. Recreation > G Geography (General)
Depositing User: APLOS Library
Date Deposited: 06 Jun 2022 13:13
Last Modified: 06 Jun 2022 13:13

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